Capsaicin's Targeted Action: How Capsicum Plaster Impacts Pain PathwaysRelease time：2023-11-10 Click：59
Capsaicin, the active ingredient in chili peppers, offers targeted pain relief when delivered transdermally through capsicum plaster. This topical analgesic works by decreasing the amount of substance P, a neurotransmitter that sends pain signals to the brain. When capsaicin comes in contact with pain receptors, it causes initial activation followed by depletion of substance P, disrupting the transmission of pain signals.
capsicum plaster enables capsaicin to be delivered directly at the site of pain. This topical application results in localized desensitization, so the affected nerves' pain signals are no longer effectively transmitted. Research shows capsaicin plasters containing 8% capsaicin can provide substantial pain relief for up to 12 weeks in patients with neuropathy, low back pain, osteoarthritis, and other chronic pain conditions.
TRPV1 Receptors - Capsaicin activates TRPV1 receptors which play a crucial role in inflammatory pain and transmission of thermal sensations. Continued activation depletes the pain neurotransmitters.
Substance P - By decreasing substance P, capsaicin disrupts the communication of pain signals to the brain resulting in pain relief. This reduction can last for weeks.
Inflammatory Mediators - Capsaicin has been shown to inhibit the production of inflammatory mediators like NF-kB that regulate pro-inflammatory cytokines. This exerts an anti-inflammatory effect.
Nerve Fiber Function - Capsaicin may Reduce painful stimuli by inhibiting C-fiber and A-delta fiber function. These peripheral nerve fibers normally transmit pain signals.
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